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Livres
Articles (101)
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Alzheimer's Disease: New Light on Etiology and Management

Nikolaos K. Robakis

Journal:

Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine

Année:

2010

Langue:

english

Fichier:

PDF, 58 KB

english, 2010

Cellular mechanisms of γ-secretase substrate selection, processing and toxicity

Gael Barthet, Anastasios Georgakopoulos, Nikolaos K. Robakis

Journal:

Progress in Neurobiology

Année:

2012

Langue:

english

Fichier:

PDF, 1.56 MB

english, 2012

The Alzheimer's amyloid precursor protein is produced by type I astrocytes in primary cultures of rat neuroglia

F. Berkenbosch, L. M. Refolo, V. L. Friedrich Jr., D. Casper, M. Blum, Dr. Nikolaos K. Robakis

Journal:

Journal of Neuroscience Research

Année:

1990

Langue:

english

Fichier:

PDF, 972 KB

english, 1990

Full-Length and Truncated Alzheimer Amyloid Precursors in Chromaffin Granules: Solubilization of Membrane Amyloid Precursor Is Mediated by an Enzymatic Mechanism

Dido Vassilacopoulou, James A. Ripellino, Nikolaos Tezapsidis, Vivian Y. H. Hook, Nikolaos K. Robakis

Journal:

Journal of Neurochemistry

Année:

1995

Langue:

english

Fichier:

PDF, 830 KB

english, 1995

Expression of the Chondroitin Sulfate Proteoglycans of Amyloid Precursor (Appican) and Amyloid Precursor-Like Protein 2

Menelas N. Pangalos, Junichi Shioi, Nikolaos K. Robakis

Journal:

Journal of Neurochemistry

Année:

1995

Langue:

english

Fichier:

PDF, 997 KB

english, 1995

Intracellular Cyclic AMP Inhibits Constitutive and Phorbol Ester-Stimulated Secretory Cleavage of Amyloid Precursor Protein

Spiros Efthimiopoulos, Suzy Punj, Vangelis Manolopoulos, Menelas Pangalos, Gian P. Wang, Lawrence M. Refolo, Nikolaos K. Robakis

Journal:

Journal of Neurochemistry

Année:

1996

Langue:

english

Fichier:

PDF, 449 KB

english, 1996

Enrichment of Presenilin 1 Peptides in Neuronal Large Dense-Core and Somatodendritic Clathrin-Coated Vesicles

Spiros Efthimiopoulos, Erik Floor, Anastasios Georgakopoulos, Junichi Shioi, Wen Cui, Sukkid Yasothornsrikul, Vivian Y. H. Hook, Thomas Wisniewski, Luc Buee, Nikolaos K. Robakis

Journal:

Journal of Neurochemistry

Année:

1998

Langue:

english

Fichier:

PDF, 1000 KB

english, 1998

Distinct Secretases, a Cysteine Protease and a Serine Protease, Generate the C Termini of Amyloid β-Proteins Aβ1-40 and Aβ1-42, Respectively

Maria E. Figueiredo-Pereira, Spiros Efthimiopoulos, Nikolaos Tezapsidis, Angeliki Buku, Jorge Ghiso, Pankaj Mehta, Nikolaos K. Robakis

Journal:

Journal of Neurochemistry

Année:

1999

Langue:

english

Fichier:

PDF, 196 KB

english, 1999

Presenilin-1 expression in Pick’s disease

P. Giannakopoulos, Enikò Kövari, Luc Buée, Junichi Shioi, Patrick R. Hof, Nikolaos K. Robakis, Constantin Bouras

Journal:

Acta Neuropathologica

Année:

1999

Langue:

english

Fichier:

PDF, 219 KB

english, 1999

Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation

Ioannis E. Michailidis, Radda Rusinova, Anastasios Georgakopoulos, Yibang Chen, Ravi Iyengar, Nikolaos K. Robakis, Diomedes E. Logothetis, Lia Baki

Journal:

Pflügers Archiv European Journal of Physiology

Année:

2011

Langue:

english

Fichier:

PDF, 473 KB

english, 2011

The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males

Panos Roussos, Stella G Giakoumaki, Anastasios Georgakopoulos, Nikolaos K Robakis, Panos Bitsios

Journal:

Bipolar Disorders

Année:

2011

Langue:

english

Fichier:

PDF, 161 KB

english, 2011

An Alternative Secretase Cleavage Produces Soluble Alzheimer Amyloid Precursor Protein Containing a Potentially Amyloidogenic Sequence

John P. Anderson, Yu Chen, Kwang S. Kim, Nikolaos K. Robakis

Journal:

Journal of Neurochemistry

Année:

1992

Langue:

english

Fichier:

PDF, 436 KB

english, 1992

The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of Aβ precursors

Georgia Agiostratidou, Rosa Miñana Muros, Junichi Shioi, Philippe Marambaud, Nikolaos K. Robakis

Journal:

Journal of Neurochemistry

Année:

2006

Langue:

english

Fichier:

PDF, 234 KB

english, 2006

FAD mutants unable to increase neurotoxic Aβ 42 suggest that mutation effects on neurodegeneration may be independent of effects on Aβ

Junichi Shioi, Anastasios Georgakopoulos, Pankaj Mehta, Zen Kouchi, Claudia M. Litterst, Lia Baki, Nikolaos K. Robakis

Journal:

Journal of Neurochemistry

Année:

2007

Langue:

english

Fichier:

PDF, 617 KB

english, 2007

Presenilin-1: A Component of Synaptic and Endothelial Adherens Junctions

ANASTASIOS GEORGAKOPOULOS, PHILIPPE MARAMBAUD, VICTOR L. FRIEDRICH JR., JUNICHI SHIOI, SPIROS EFTHIMIOPOULOS, NIKOLAOS K. ROBAKIS

Journal:

Annals of the New York Academy of Sciences

Année:

2000

Langue:

english

Fichier:

PDF, 770 KB

english, 2000

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

Baki, Lia, Shioi, Junichi, Wen, Paul, Shao, Zhiping, Schwarzman, Alexander, Gama-Sosa, Miguel, Neve, Rachael, Robakis, Nikolaos K

Journal:

The EMBO Journal

Année:

2004

Langue:

english

Fichier:

PDF, 274 KB

english, 2004

Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling

Georgakopoulos, Anastasios, Litterst, Claudia, Ghersi, Enrico, Baki, Lia, Xu, ChiJie, Serban, Geo, Robakis, Nikolaos K

Journal:

The EMBO Journal

Année:

2006

Langue:

english

Fichier:

PDF, 412 KB

english, 2006

The genetics of Familial Alzheimer’s Disease

Evelyn A. Devine-Gage, Edmund C. Jenkins, W. Ted Brown, Nikolaos K. Robakis, Henryk M. Wisniewski

Journal:

AGE

Année:

1988

Langue:

english

Fichier:

PDF, 477 KB

english, 1988

Overexpression of Wild Type But Not an FAD Mutant Presenilin-1 Promotes Neurogenesis in the Hippocampus of Adult Mice

Paul H. Wen, Xiang Shao, Zhiping Shao, Patrick R. Hof, Thomas Wisniewski, Kevin Kelley, Victor L. Friedrich Jr., Lap Ho, Giulio M. Pasinetti, Junichi Shioi, Nikolaos K. Robakis, Gregory A. Elder

Journal:

Neurobiology of Disease

Année:

2002

Langue:

english

Fichier:

PDF, 561 KB

english, 2002

In vitro expression of Escherichia coli ribosomal protein L10 gene: Tripeptide synthesis as a measure of functional mRNA

Yves Cenatiempo, Nikolaos Robakis, Brian R. Reid, Herbert Weissbach, Nathan Brot

Journal:

Archives of Biochemistry and Biophysics

Année:

1982

Langue:

english

Fichier:

PDF, 595 KB

english, 1982

Localization of a human gene homologous to the PrP gene on the p ARM of chromosome 20 and detection of PrP-related antigens in normal human brain

Nikolaos K. Robakis, Evelyn A. Devine-Gage, Edmund C. Jenkins, Richard J. Kascsak, W.Ted Brown, Michael S. Krawczun, Wayne P. Silverman

Journal:

Biochemical and Biophysical Research Communications

Année:

1986

Langue:

english

Fichier:

PDF, 1.39 MB

english, 1986

Fine mapping of an Alzheimer Disease-associated gene encoding beta-amyloid protein

Edmund C. Jenkins, Evelyn A. Devine-Gage, Nikolaos K. Robakis, Xiu-Lan Yao, W.Ted Brown, George E. Houck Jr., Gloria Wolfe, Narayanarao Ramakrishna, Wayne P. Silverman, Henryk M. Wisniewski

Journal:

Biochemical and Biophysical Research Communications

Année:

1988

Langue:

english

Fichier:

PDF, 745 KB

english, 1988

Nerve and epidermal growth factors induce the release of the Alzheimer Amyloid precursor from PC 12 cell cultures

Lawrence M. Refolo, Steven R.J. Salton, John P. Anderson, Pankaj Mehta, Nikolaos K. Robakis

Journal:

Biochemical and Biophysical Research Communications

Année:

1989

Langue:

english

Fichier:

PDF, 1.59 MB

english, 1989

Characterization of the 5′-end region and the first two exons of the β-protein precursor gene

Giuseppe La Fauci, Debomoy K. Lahiri, Stephen R.J. Salton, Nikolaos K. Robakis

Journal:

Biochemical and Biophysical Research Communications

Année:

1989

Langue:

english

Fichier:

PDF, 878 KB

english, 1989

Binding of vascular heparan sulfate proteoglycan to Alzheimer's amyloid precursor protein is mediated in part by the N-terminal region of A4 peptide

Luc Buée, Wanhong Ding, John P. Anderson, Suree Narindrasorasak, Robert Kisilevsky, Noel J. Boyle, Nikolaos K. Robakis, André Delacourte, Barry Greenberg, Howard M. Fillit

Journal:

Brain Research

Année:

1993

Langue:

english

Fichier:

PDF, 609 KB

english, 1993

The presenilin-1 familial Alzheimer's disease mutation P117L decreases neuronal differentiation of embryonic murine neural progenitor cells

Lorenza Eder-Colli, Noelia Abad-Estarlich, Carine Pannetier, Philippe G. Vallet, Claude Walzer, Gregory A. Elder, Nikolaos K. Robakis, Constantin Bouras, Armand Savioz

Journal:

Brain Research Bulletin

Année:

2009

Langue:

english

Fichier:

PDF, 1.60 MB

english, 2009

A CBP Binding Transcriptional Repressor Produced by the PS1/ϵ-Cleavage of N-Cadherin Is Inhibited by PS1 FAD Mutations

Philippe Marambaud, Paul H Wen, Anindita Dutt, Junichi Shioi, Akihiko Takashima, Robert Siman, Nikolaos K Robakis

Journal:

Cell

Année:

2003

Langue:

english

Fichier:

PDF, 544 KB

english, 2003

The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice

Paul H. Wen, Patrick R. Hof, Xiaoping Chen, Karen Gluck, Gregory Austin, Steven G. Younkin, Linda H. Younkin, Rita DeGasperi, Miguel A. Gama Sosa, Nikolaos K. Robakis, Vahram Haroutunian, Gregory A. E

Journal:

Experimental Neurology

Année:

2004

Langue:

english

Fichier:

PDF, 763 KB

english, 2004

Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives

Nikolaos K. Robakis

Journal:

Neurobiology of Aging

Année:

2011

Langue:

english

Fichier:

PDF, 712 KB

english, 2011

Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling

Jindong Xu, Maria Xilouri, Julien Bruban, Junichi Shioi, Zhiping Shao, Ioannis Papazoglou, Kostas Vekrellis, Nikolaos K. Robakis

Journal:

Neurobiology of Aging

Année:

2011

Langue:

english

Fichier:

PDF, 1.90 MB

english, 2011

Chondroitin sulfate of appican, the proteoglycan form of amyloid precursor protein, produced by C6 glioma cells interacts with heparin-binding neuroregulatory factors

Yuko Umehara, Shuhei Yamada, Shuji Nishimura, Junichi Shioi, Nikolaos K. Robakis, Kazuyuki Sugahara

Journal:

FEBS Letters

Année:

2004

Langue:

english

Fichier:

PDF, 154 KB

english, 2004

Alzheimer's disease: a re-examination of the amyloid hypothesis

Rachael L. Neve, Nikolaos K. Robakis

Journal:

Trends in Neurosciences

Année:

1998

Langue:

english

Fichier:

PDF, 111 KB

english, 1998

Amyloid β peptides activate the phosphoinositide signaling pathway in oocytes expressing rat brain RNA

Robert D Blitzer, Tony Wong, Maria G Giovannini, Menalas N Pangalos, Nikolaos K Robakis, Emmanuel M Landau

Journal:

Molecular Brain Research

Année:

2000

Langue:

english

Fichier:

PDF, 136 KB

english, 2000

Molecular organization of presenilin 1 in the E-cadherin/catenins cell adhesion system

Philippe Marambaud, Lia Baki, Anastasios Georgakopoulos, Junichi Shioi, Spiros Efthimiopoulos, Masayuki Ozawa, Nikolaos K. Robakis

Journal:

Neurobiology of Aging

Année:

2000

Langue:

english

Fichier:

PDF, 190 KB

english, 2000

Localization of presenilin at synaptic sites

Tassos Georgakopoulos, Junichi Shioi, Ronald Gordon, Gay R. Holstein, Giorgio Martinelli, Spiros Efthimiopoulos, Victor L. Friedrich, Nikolaos K. Robakis

Journal:

Neurobiology of Aging

Année:

2000

Langue:

english

Fichier:

PDF, 186 KB

english, 2000

Chemical characterization of appican's chondrotin sulfate glycosaminoglycan chains

Junichi Shioi, Kazunori Tsuchida, Shuhei Yamada, Kazuyuki Sugahara, Garen Boghosian, Anfan Wu, Hongying Cai, Nikolaos K. Robakis

Journal:

Neurobiology of Aging

Année:

2000

Langue:

english

Fichier:

PDF, 153 KB

english, 2000

PS1 is a regulatory component of the cadherin/catenin adherens junction system

Lia Baki, Philippe Marambaud, Spiros Efthimiopoulos, Paul Wen, Tassos Georgakopoulos, Nikolaos K. Robakis

Journal:

Neurobiology of Aging

Année:

2000

Langue:

english

Fichier:

PDF, 113 KB

english, 2000

PL-4-1 Alzheimer's disease: emerging pathogenic mechanisms based on inhibition of PS1 function in signal transduction

Nikolaos K. Robakis

Journal:

Neurobiology of Aging

Année:

2004

Langue:

english

Fichier:

PDF, 152 KB

english, 2004

O3-05-02 FAD-linked presenilin-1 mutations affect the N-cadherin/CBP signaling pathway via a loss-of-function mechanism

Philippe Marambaud, Paul H. Wen, Anindita Dutt, Junichi Shioi, Geo Serban, Akihiko Takashima, Robert Siman, Nikolaos K. Robakis

Journal:

Neurobiology of Aging

Année:

2004

Langue:

english

Fichier:

PDF, 313 KB

english, 2004

P1-232 The E-cadherin intracellular fragment, released by the γ-secretase-like cleavage, stimulates degradation of the precursors of Abeta peptide

Georgia Agiostratidou, Rosa Minana, Junishi Shoi, Nikolaos K. Robakis

Journal:

Neurobiology of Aging

Année:

2004

Langue:

english

Fichier:

PDF, 159 KB

english, 2004

Presenilin-1 is expressed in neural progenitor cells in the hippocampus of adult mice

Paul H. Wen, Victor L. Friedrich Jr, Junichi Shioi, Nikolaos K. Robakis, Gregory A. Elder

Journal:

Neuroscience Letters

Année:

2002

Langue:

english

Fichier:

PDF, 201 KB

english, 2002

Conformation of free and ribosome bound rRNAs from E.coli

Nikolaos Robakis, Miloslav Boublik

Journal:

Biochemical and Biophysical Research Communications

Année:

1981

Langue:

english

Fichier:

PDF, 447 KB

english, 1981

Guanosine-5′-diphosphate-3′-diphosphate inhibits the in, vitro synthesis of β-lactamase from pBR322 DNA

Luis Meza-Basso, Nikolaos Robakis, Yves Cenatiempo, Herbert Weissbach, Nathan Brot

Journal:

Biochemical and Biophysical Research Communications

Année:

1981

Langue:

english

Fichier:

PDF, 833 KB

english, 1981

Expression of beta-amyloid precursor protein on neuron plasma membranes

Larry D. Altstiel, Nikolaos K. Robakis

Journal:

Biological Psychiatry

Année:

1989

Langue:

english

Fichier:

PDF, 181 KB

english, 1989

Processing and regional specificity of variant forms of the Alzheimer amyloid precursor protein

John P. Anderson, Lawrence M. Refolo, Vahram Haroutunian, Linda Bierer, Daniel Perl, Nikolaos K. Robakis, Kenneth L. Davis

Journal:

Biological Psychiatry

Année:

1989

Langue:

english

Fichier:

PDF, 181 KB

english, 1989

Characterization of newly synthesized beta-amyloid precursor protein in rat and human

William Wallace, Mani Krishnamurthi, Jason Gotlib, Lawrence Refolo, Vahram Haroutunian, Nikolaos K. Robakis

Journal:

Biological Psychiatry

Année:

1989

Langue:

english

Fichier:

PDF, 97 KB

english, 1989

O3-03-02: PS1/γ-secretase regulate the EphB-induced Src signaling

Anastasios Georgakopoulos, Claudia Litterst, Enrico Ghersi, Lia Baki, Chijie Xu, Geo Serban, Nikolaos K. Robakis

Journal:

Alzheimer's & Dementia

Année:

2006

Langue:

english

Fichier:

PDF, 67 KB

english, 2006

Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors

Gael Barthet, Julie Dunys, Zhiping Shao, Zhao Xuan, Yimin Ren, Jindong Xu, Nicolas Arbez, Gweltas Mauger, Julien Bruban, Anastasios Georgakopoulos, Junichi Shioi, Nikolaos K. Robakis

Journal:

Neurobiology of Aging

Année:

2013

Langue:

english

Fichier:

PDF, 1.86 MB

english, 2013

Characterization of Appican, the Chondroitin Sulfate Proteoglycan Form of the Alzheimer Amyloid Precursor Protein

Menelas N. Pangalos, Junichi Shioi, Spiros Efthimiopoulos, Anfan Wu, Nikolaos K. Robakis

Journal:

Neurodegeneration

Année:

1996

Langue:

english

Fichier:

PDF, 75 KB

english, 1996

Oxygen-free radicals and amyloidosis in alzheimer's disease: Is there a connection?

Nikolaos K. Robakis, Miguel A. Pappolla

Journal:

Neurobiology of Aging

Année:

1994

Langue:

english

Fichier:

PDF, 318 KB

english, 1994